HYDROTROPIC SOLUBILIZATION PDF

Published29 Oct Abstract Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2 M sodium benzoate as the hydrotropic agent.

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Metrics details Abstract Purpose. This study examines the mechanism of hydrotropic solubilization using the riboflavin-nicotinamide system. The most commonly proposed mechanism for hydrotropic solubilization is complexation, and therefore, is investigated.

Additionally, since nicotinamide and several other hydrotropic agents self-associate in aqueous solution, the possibility that self-association of the hydrotropic agent is important mechanistically is examined by studying the effect of temperature on hydrotropic ability. Researchers have shown that the degree of self-association decreases with increasing temperature. Therefore, if temperature affects the solubilizing capacity of nicotinamide, self-association must be mechanistically significant.

The solubility of riboflavin in nicotinamide solutions as a function of temperature is determined to assess the impact of self-association on hydrotropicity. Temperature does have an effect on the hydrotropic ability of nicotinamide.

Specifically, as temperature increases, the solubilizing capacity of nicotinamide decreases. Because nicotinamide is unable to quench riboflavin fluorescence, and does not produce significant spectral changes, complexation of nicotinamide and riboflavin does not occur. However, since increasing temperature causes a decrease in the hydrotropic ability of nicotinamide and in its degree of self-association, it is proposed here that the self-association of nicotinamide impacts the hydrotropic mechanism.

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Agrawal and M. ABSTRACT: Solubility of drug is considered to be one of the crucial parameter to achieve its desired concentration in systemic circulation and better pharmacological response. As most of the drugs available are poorly aqueous soluble, solubility enhancement has become major challenge to the formulators in the product development of many orally administered drugs. Therapeutic response of drug as well bioavailability can be limited by poor aqueous solubility of drugs. Earlier, many techniques have been developed for enhancing solubility of drugs. Apart from those, hydrotropic solubilization is one of the solubility enhancement techniques applicable to enhance solubility of hydrophobic drugs with the use of hydrotropes like sodium benzoate, urea, piperazine etc. In the present investigation Lumefantrine, an anti malarial drug was selected as model drug for the reason it has very low water solubility of 0.

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Get e-Alerts Abstract Hydrotropic solubilization of total boswellic acids from Boswellia serrata gum resins has been investigated with aqueous solutions of alkylbenzene sulfonate hydrotropes. Due to their amphiphilic structures, the hydrotropes cooperatively form microassemblies in aqueous solutions which, in turn, are responsible for the solubilization of water-insoluble organic substances. The solubility of boswellic acids was increased by 2 orders of magnitude in the presence of hydrotropes in aqueous solutions. The effect of hydrotrope concentration on the solubility was investigated in detail along with the kinetics of solubilization.

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