FORMULARIO SAT 0052 PDF

Misar US USA1 en After 12 hours the reaction was cooled to room temperature and diluted with ethyl acetate 70 mL and washed with water. For specific examples, see M. Prevention of the action of microorganisms can be ensured by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, and the like. A spiro ring system is not a fused-polycyclic by this definition, but fused polycyclic ring systems of the invention may themselves have spiro rings attached thereto via a single ring atom of the fused-polycyclic. The mixture was diluted with dichloromethane, washed with sat.

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Misar US USA1 en After 12 hours the reaction was cooled to room temperature and diluted with ethyl acetate 70 mL and washed with water. For specific examples, see M. Prevention of the action of microorganisms can be ensured by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, and the like. A spiro ring system is not a fused-polycyclic by this definition, but fused polycyclic ring systems of the invention may themselves have spiro rings attached thereto via a single ring atom of the fused-polycyclic.

The mixture was diluted with dichloromethane, washed with sat. To the fformulario solution, m-CPBA As a global community, we continuously invest and commit to advancing human health. These schemes are merely illustrative of some methods by which the compounds of this invention can be synthesized, and various modifications to these schemes can be made and will be suggested formularko one skilled in the art having referred to this disclosure. More specifically, R 6 is pyridinyl, pyrazinyl, pyrimidinyl, or pyridazinyl each of which is optionally substituted with one R 9 where R 9when present, is halo.

The reaction was stirred for 2 h at room temperature. The Compound of Claim 3 where R 6 is phenyl optionally substituted with 1, 2, or 3 R 9 groups. Specifically, each R 9when present, is independently alkyl, arylalkyl, cyano, aryl, alkoxycarbonyl, or halo. The fractions containing product were collected and concentrated to one half volume and poured into saturated NaHCO 3 50 mL.

The reaction mixture was heated to 0 C and allowed to stir overnight. The residue was purified on SiO 2. In another example, a biologically active metabolite is discovered serendipitously, that is, no prodrug design per se was undertaken.

Department of History, University of Toronto Posted: R 4 is hydrogen, halo, haloalkyl, haloalkoxy, -NR 3a — optionally substituted alkyl, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 1 -C 6 alkoxyalkyl, optionally substituted aminoalkyl, optionally substituted C 3 -C 7 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

The mixture is then washed with water and dried over a drying agent such as Na 2 SO 4 to yield 6. Some of the compounds of the invention may exist as tautomers. Recently, pharmaceutical formulations fprmulario been developed especially for drugs that show poor bioavailability based upon the principle that bioavailability can be increased by increasing the surface area i.

All references cited herein are incorporated by reference in their entirety. The Compound of Claim 25 where R 6 is phenyl optionally substituted with 1, 2, or 3 R 9 groups. It allows PDF version of manuscripts that have been peer reviewed and accepted, to be hosted online prior to their inclusion in a final printed journal. A Compound of Formula I:.

The Compound of Claim 3 where R 6 is pyrazolyl, imidazolyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, oxadiazolyl, furanyl, pyrrolyl, , or tetrazolyl; each of which is optionally substituted with 1, 2, or 3 R 9 groups. Salts derived from pharmaceutically acceptable organic non-toxic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins.

The residue was purified on SiO 2 3: Sample was filtered through a syringe filter and evaporated to dryness. The aqueous phase was separated and washed once more with ethyl acetate mL.

Summary of the Related Art. Learn more about our Department at http: R 1 is hydrogen, optionally substituted alkyl, optionally substituted C 3 -C 7 cycloalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heterocycloalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl.

Enantiomers R- and S -isomers may be resolved by methods known to one of ordinary skill in the art, for example by: The Compound of Claim 3 where R 1 is heterocycloalkyl fotmulario R 4 is methyl. In particular, the invention relates to inhibitors of phosphatidylinositol 3-kinase PBK signaling pathways, and methods of their use. R 2 is hydrogen or alkyl where the alkyl is optionally substituted with 1, 2, 3, 4, formuladio 5 R 8 groups.

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FORMULARIO SAT 0052 PDF

Yozuru Abstracts and full articles may be submitted in either Spanish or English. For example, hexahydro-furo[3,2-b]furan, 2,3,3a,4,7,7a-hexahydro-lH-indene, 7-aza-bicyclo[2. In the event of a discrepancy between the express disclosure of this specification and the references incorporated by reference, the express disclosure of this specification shall control. The project starts on 1 January and is of 24 months duration.

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