ENFERMEDAD GRANULOMATOSA CRONICA PDF

An infection in the lungs, including pneumonia, is common. People with CGD may develop a serious type of fungal pneumonia after being exposed to dead leaves, mulch or hay. Signs and symptoms associated with infections include: Fever Chest pain when inhaling or exhaling Swollen and sore lymph glands A persistent runny nose Skin irritation that may include a rash, swelling or redness Swelling and redness in your mouth Gastrointestinal problems that may include vomiting, diarrhea, stomach pain, bloody stool or a painful pocket of pus near the anus When to see a doctor If you think you or your child has a type of fungal pneumonia from being around dead leaves, mulch or hay, get medical care right away. If you or your child has frequent infections and the signs and symptoms listed above, talk to your doctor.

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Su frecuencia en Estados Unidos es de aproximadamente , nacidos vivos. Las infecciones son causadas generalmente por microorganismos catalasa-positivos. Chronic granulomatous disease. Abstract Chronic granulomatous disease CGD is a genetically heterogeneous condition characterized by recurrent, life-threatening bacterial and fungal infections and granuloma formation. CGD is caused by defects in the phagocyte nicotinamide adenine dinucleotide phosphate NADPH oxidase, which constitutes the phagocyte oxidase phox.

These genetic defects result in the inability of phagocytes neutrophils, monocytes, and macrophages to destroy certain microbes. The diagnosis is made by neutrophil function testing, and then the exact defect is determined by genotyping.

Infections are generally caused by catalase-positive micro-organisms most bacterial and all fungal pathogens are catalase positive. The frequent sites of infection are lung, skin, lymph nodes, and liver. The formation of granulomata is especially problematic in the gastrointestinal and genitourinary tracts.

May present at any time from infancy to late adulthood, but the majority of patients are diagnosed as toddlers and children before the age of five years. Whereby emphasis is made on the clinical significance of this case, which occurs in an older adult.

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