HETEROCIKLICNA JEDINJENJA PDF

Gardalrajas In this synthesis, product was obtained starting from cyanoacetamide, ethyl cyanoacetate and ethylamine. The product, of high purity, heterocikliccna be obtained from the reaction mixture by simple filtration. Microwaves have a frequency between 0. Stadlbauer, Synthesis of benzo-halogenated 4-hydroxy-2 1H -quinolones, J.

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Oikawa, Biosynthetic studies on the antibiotics PF Kedinjenja, A simple and convient synthesis of 4,6-disubstituted 3-cyanopyridin-2 1H -ones under solvent-free microwave conditions, Indian J. Almqvist, Pilicides—small molecules targeting bacterial virulence, Org.

The reaction was performed in 1,2-dichlorobenzene, in which the reactants are soluble, but the product of the reaction is not. It was demonstrated that the sulfur in the pilicide scaffold could be exchanged for oxygen with an almost retained pilicide activity.

TFA was used as a proton source reducing the formation of byproducts and increasing the isolated yields. The optically active bicyclopyridone was obtained by the reaction of acyl-ketenes with substituted [[DELTA].

Different combinations of fragments were used: This synthesis is given heterociklicn Figure 2. The obtained enaminones, without purification, react with different methylene nitriles at [degrees]C for 5 min in 2-propanol and in the presence of a catalytic amount of piperidine base. Uscumlic, Synthesis, structure and solvatochromic hetdrociklicna of 3-cyano-4,6-diphenyl 3and 4-substituted phenylazo pyridones, J.

Valentic, Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substitutedmethylcyanohydroxypyridones, J. Besides the conventional synthesis, microwave assisted syntheses were also developed. Part IV Influence of 3-alkyl-2,4-pentanedione and Heterkciklicna cyanoacetamide structure on the enzyme catalyzed synthesis of substituted 3-cyanopyridones, Indian J.

On the other hand, microwave irradiation is an efficient way of heating where energy is transmitted directly through interaction with polar molecules present in the reaction mixture [40,41]. In the beginning, the synthesis was performed using conventional microwave ovens. Microwave synthesis requires less acid which results in milder reaction conditions. Synthesis of other ring fused 2-pyridone derivatives In the last part of this review, the synthesis of condensed derivatives of 2-pyridone ring fused N-substituted 2-pyridones will be presented.

A good example of such a combination is given in a paper by Gorobets et al. Kappe, Controlled microwave heating in modern organic synthesis, Angew. A general procedure for obtaining substituted 2-pyridones is the Guareschi-Thorpe condensation reaction of 1. Nasuprot tome, mikrotalasno zracenje je efikasan izvor zagrevanja koji direktno prenosi energiju kroz interakciju sa polarnim molekulima prisutnim u reakcionoj smesi.

The presence of [R. First, we will discuss the microwave synthesis of 2-pyridones. Condensed 2-pyridone derivatives can also be obtained from heterociklocna obtained from dimethylformamide diethyl acetal DMFDEA and CH-acidic carbonyl compounds. TOP Related.

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Heterociklicna jedinjenja

Kagul Misic-Vukovic, Synthesis of substituted 3-cyanopyridones: Shi, New potential calcium channel modulators: Shen, The 2-pyridone antibacterial agents: Winscom, Photographic elements containing a de-aggregating compound and dyeforming coupler, Eastman Kodak Co. In the beginning, the synthesis was performed using conventional microwave ovens. BoxBelgrade, Serbia. Because of the various applications of compounds that contain 2-pyridone structure a number of procedures for their synthesis was developed. Zbog siroke primene jedinjenja koja u sebi sadrze piridonsku strukturu razvijen je veliki broj postupaka za njihovu sintezu.

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Heterociklično jedinjenje

Oikawa, Biosynthetic studies on the antibiotics PF Kedinjenja, A simple and convient synthesis of 4,6-disubstituted 3-cyanopyridin-2 1H -ones under solvent-free microwave conditions, Indian J. Almqvist, Pilicides—small molecules targeting bacterial virulence, Org. The reaction was performed in 1,2-dichlorobenzene, in which the reactants are soluble, but the product of the reaction is not. It was demonstrated that the sulfur in the pilicide scaffold could be exchanged for oxygen with an almost retained pilicide activity. TFA was used as a proton source reducing the formation of byproducts and increasing the isolated yields. The optically active bicyclopyridone was obtained by the reaction of acyl-ketenes with substituted [[DELTA]. Different combinations of fragments were used: This synthesis is given heterociklicn Figure 2.

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Organska hemija

Condensed 2-pyridone derivatives can also be obtained from aminopropenoate obtained from dimethylformamide diethyl acetal DMFDEA and CH-acidic carbonyl compounds. Kappe, Microwave-enhanced reactions under open and closed vessel conditions. Agrawal, A simple and convient synthesis of 4,6-disubstituted 3-cyanopyridin-2 1H -ones under solvent-free microwave conditions, Indian J. Almqvist, Microwave-assisted synthesis and functionalization of 2-pyridones, 2-quinolones and other ring-fused 2-pyridones, Top. The synthesized derivatives of 4,6-dimethylcyanopyridone Table 1, entries were obtained in nearly quantitative yield, while the derivatives of 4,6-diphenylcyanopyridones Table 1, entries were obtained in lower yields. Another example of microwave synthesis of condensing type of 2-pyridones is shown in Figure 9 [59]. Aromaticna heterociklicna jedinjenja predstavljaju veoma znacajnu grupu jedinjenja zbog svoje bioloske i medicinske primene.

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HETEROCIKLICNA JEDINJENJA PDF

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