JANEWAY INMUNOLOGIA PDF

Doulrajas She argues that immunologists have had overly simplistic and schematic ideas about immune response because of the limits of their assays, and that organs are likely to induce immune responses that are best-suited to defending the organ from the damage of microbes but also from the damage of the immune system itself. The justification for this approach is that the absence of one or more components of the immune system is virtually always made clear by an increased susceptibility to one or more specific infections. Zoomed all the way out, the Kindle version looks exactly like the print version. I did use a janesay supplemental book to help me understand the subject, which was excellent!!

Author:Muk Malarn
Country:Austria
Language:English (Spanish)
Genre:Sex
Published (Last):5 June 2007
Pages:49
PDF File Size:1.77 Mb
ePub File Size:9.3 Mb
ISBN:934-5-17978-395-7
Downloads:94681
Price:Free* [*Free Regsitration Required]
Uploader:Narn



The humoral immune response is initiated when B cells that bind antigen are signaled by helper T cells or by certain microbial antigens alone Armed helper T cells activate B cells that recognize the same antigen Antigenic peptides bound to self MHC class II molecules trigger armed helper T cells to make membrane-bound and secreted molecules that can activate a B cell Isotype switching requires expression of CD40L by the helper T cell and is directed by cytokines Antigen-binding B cells are trapped in the T-cell zone of secondary lymphoid tissues and are activated by encounter with armed helper T cells The second phase of the primary B-cell immune response occurs when activated B cells migrate to follicles and proliferate to form germinal centers Germinal center B cells undergo V-region somatic hypermutation and cells with mutations that improve affinity for antigen are selected Ligation of the B-cell receptor and CD40, together with direct contact with T cells, are all required to sustain germinal center B cells Surviving germinal center B cells differentiate into either plasma cells or memory cells B-cell responses to bacterial antigens with intrinsic ability to activate B cells do not require T-cell help B-cell responses to bacterial polysaccharides do not require peptide-specific T-cell help Summary The distribution and functions of immunoglobulin isotypes Antibodies of different isotype operate in distinct places and have distinct effector functions Transport proteins that bind to the Fc regions of antibodies carry particular isotypes across epithelial barriers High-affinity IgG and IgA antibodies can neutralize bacterial toxins High-affinity IgG and IgA antibodies can inhibit the infectivity of viruses Antibodies can block the adherence of bacteria to host cells Antibody:antigen complexes activate the classical pathway of complement by binding to C1q Complement receptors are important in the removal of immune complexes from the circulation Summary The destruction of antibody-coated pathogens via Fc receptors The Fc receptors of accessory cells are signaling receptors specific for immunoglobulins of different isotypes Fc receptors on phagocytes are activated by antibodies bound to the surface of pathogens and enable the phagocytes to ingest and destroy pathogens Fc receptors activate natural killer cells to destroy antibody-coated targets Adaptive Immunity to Infection Infectious agents and how they cause disease The course of an infection can be divided into several distinct phases Infectious diseases are caused by diverse living agents that replicate in their hosts Summary The course of the adaptive response to infection The nonspecific responses of innate immunity are necessary for an adaptive immune response to be initiated An adaptive immune response is initiated when circulating T cells encounter their corresponding antigen in draining lymphoid tissues and become activated Cytokines made in the early phases of an infection influence the functional differentiation of CD4 T cells Distinct subsets of T cells can regulate the growth and effector functions of other T-cell subsets The nature and amount of antigenic peptide can also affect the differentiation of CD4 T cells Armed effector T cells are guided to sites of infection by chemokines and newly expressed adhesion molecules Antibody responses develop in lymphoid tissues under the direction of armed helper T cells Antibody responses are sustained in medullary cords and bone marrow The effector mechanisms used to clear an infection depend on the infectious agent Resolution of an infection is accompanied by the death of most of the effector cells and the generation of memory cells Summary Mucosa-associated lymphoid tissue is located in anatomically defined microcompartments throughout the gut The mucosal immune system contains a distinctive repertoire of lymphocytes Secretory IgA is the antibody isotype associated with the mucosal immune system Most antigens presented to the mucosal immune system induce tolerance The mucosal immune system can mount an immune response to the normal bacterial flora of the gut Enteric pathogens cause a local inflammatory response and the development of protective immunity Infection by Helicobacter pylori causes a chronic inflammatory response, which may cause peptic ulcers, carcinoma of the stomach, and unusual lymphoid tumors In the absence of inflammatory stimuli, the normal response of the mucosal immune system to foreign antigens is tolerance Summary Immunological memory is long-lived after infection or vaccination Both clonal expansion and clonal differentiation contribute to immunological memory in B cells Repeated immunizations lead to increasing affinity of antibody owing to somatic hypermutation and selection by antigen in germinal centers Memory T cells are increased in frequency and have distinct activation requirements and cell-surface proteins that distinguish them from armed effector T cells In immune individuals, secondary and subsequent responses are mediated solely by memory lymphocytes and not by naive lymphocytes Summary General references Section references The course of an infection can be divided into several distinct phases.

The Immune System in Health and Disease.

KLUBER ALTEMP Q NB 50 PDF

Libros de Ciencia, Medicina

Washington University School of Medicine, St. Conforme surjan nuevos conocimientos, se requerirn cambios de la teraputica. El los autor es y los editores se han esforzado para que los cuadros de dosificacin medicamentosa sean precisos y acordes con lo establecido en la fecha de publicacin. Sin embargo, ante los posibles errores humanos y cambios en la medicina, ni los editores ni cualquier otra persona que haya participado en la preparacin de la obra garantizan que la informacin contenida en ella sea precisa o completa, tampoco son responsables de errores u omisiones, ni de los resultados que con dicha informacin se obtengan. Convendra recurrir a otras fuentes de datos, por ejemplo, y de manera particular, habr que consultar la hoja informativa que se adjunta con cada medicamento, para tener certeza de que la informacin de esta obra es precisa y no se han introducido cambios en la dosis recomendada o en las contraindicaciones para su administracin.

LACHENMANN GRAN TORSO SCORE PDF

JANEWAY INMUNOLOGIA PDF

ComiXology Thousands of Digital Comics. I will say that this is not an intro level read, but it does break down complicated concepts. Retrieved 19 Jan One person found this helpful. Immunobiology — NCBI Bookshelf The justification for this approach is that the absence of one or more components of the immune system is virtually always made clear by an increased susceptibility to one or more specific infections. I bought it used from Amazon, and although the cover was a little bent since it was paperbackall in all it was in excellent shape.

THE FEMALE BRAIN LOUANN BRIZENDINE PDF

inmunologia janeway 7ed

.

KBU8K DATASHEET PDF

Inmunobiologia De Janeway

.

Related Articles